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Divergent Gemycircularvirus in HIV-Positive Blood, France.

Abstract : We retrospectively analyzed the impact of HLA-DPB1 mismatches in a large cohort of 1342 French patients who underwent 10/10 HLA-matched unrelated HSCT. A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHDIII-IV) (risk ratio (RR)=1.73, confidence interval (CI) 95% 1.09-2.73, P=0.019) without impact on OS, TRM, relapse and chronic GVHD (cGVHD). According to the T-cell epitope 3 (TCE3)/TCE4 HLA-DPB1 disparity algorithm, 37.6% and 58.4% pairs had nonpermissive HLA-DPB1, respectively. TCE3 and TCE4 disparities had no statistical impact on OS, TRM, relapse, aGVHD and cGVHD. When TCE3/TCE4 disparities were analyzed in the graft-vs-host or host-vs-graft (HVG) direction, only a significant impact of TCE4 nonpermissive disparities in the HVG direction was observed on relapse (RR=1.34, CI 95% 1.00-1.80, P=0.048). In conclusion, this French retrospective study shows an adverse prognosis of HLA-DPB1 mismatches (2 vs 0) on severe aGVHD and of nonpermissive TCE4 HVG disparities on relapse after HLA-matched 10/10 unrelated HSCT.
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Submitted on : Monday, May 31, 2021 - 4:19:53 PM
Last modification on : Tuesday, October 19, 2021 - 10:59:31 PM

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Rathviro Uch, Pierre-Edouard Fournier, Catherine Robert, Caroline Blanc-Tailleur, Vital Galicher, et al.. Divergent Gemycircularvirus in HIV-Positive Blood, France.. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2015, 21 (11), pp.2096-8. ⟨10.3201/eid2111.150486⟩. ⟨hal-01235994⟩

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