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Communication Dans Un Congrès Année : 2015

Infering an ontology of single cell motions from high-throughput microscopy data

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Cellular motility is a fundamental biological process. Progress in the fields of gene silencing and high-throughput (HT) microscopy provide us with the tools to study its molecular basis and potential perturbators. The primary contribution of this paper is to present MotIW, a generic workflow for single cell motility study in HT time-lapse screening data. We successfully apply it to a simulated screen, as well as a genome-wide screen. Furthermore, MotIW enables the identification of eigth motility patterns into which all trajectories from this dataset divide up into, without any prior model of cell motion.
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hal-02742630 , version 1 (17-11-2020)

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Alice Schoenauer Sebag, Sandra Plancade, Céline Raulet-Tomkiewicz, Robert Barouki, Jean-Philippe Vert, et al.. Infering an ontology of single cell motions from high-throughput microscopy data. IEEE 12th International Symposium on Biomedical Imaging, Apr 2015, New York, United States. pp.4, ⟨10.1109/ISBI.2015.7163840⟩. ⟨hal-02742630⟩
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