Treatment and outcomes in patients with central nervous system metastases from breast cancer in the real-life ESME MBC cohort

David Pasquier (1, 2) , Amélie Darlix (3) , Guillaume Louvel (4) , Julien Fraisse (5) , William Jacot (3) , Etienne Brain (6) , Adeline Petit (7) , Marie Ange Mouret-Reynier (8, 9) , Anthony Gonçalves (10) , Florence Dalenc (11) , Elise Deluche (12) , Jean Sébastien Fresnel , Paule Augereau (13) , Jean Marc Ferrero (14) , Julien Geffrelot (15) , Jean-David Fumet (16) , Isabelle Lecouillard (17) , Paul Cottu (18) , Thierry Petit (19) , Lionel Uwer (20) , Christelle Jouannaud (21) , Marianne Leheurteur (22) , Véronique Dieras (23) , Mathieu Robain (24) , Raphaelle Mouttet-Audouard , Thomas Bachelot (25) , Coralie Courtinard

1 UNICANCER/Lille - Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille]
2 CRIStAL - Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189
3 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier
4 CRLCC - CRLCC Eugène Marquis
5 Unité de biostatistiques
6 Department of Medical Oncology [Saint-Cloud]
7 Département de radiothérapie [Bordeaux]
8 IMoST - Imagerie Moléculaire et Stratégies Théranostiques
9 UNICANCER/CJP - Centre Jean Perrin [Clermont-Ferrand]
10 Institut Paoli-Calmettes
11 Institut Claudius Regaud
12 CHU Limoges
13 UNICANCER/ICO - Institut de Cancérologie de l'Ouest [Angers/Nantes]
14 UNICANCER/CAL - Centre de Lutte contre le Cancer Antoine Lacassagne [Nice]
15 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
16 Département d'oncologie médicale [Centre Georges-François Leclerc]
17 Service de radiothérapie
18 Département de Recherche Translationnelle
19 Centre Paul Strauss
20 UNICANCER/ICL - Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy]
21 CRLCC Jean Godinot
22 Service d'Oncologie Médicale
23 Medical Oncology Department
24 Institut Curie [Paris]
25 Oncogénèse et progression tumorale

The aims of the present study were to describe treatment patterns and survival outcomes in patients with central nervous system metastases (CNSM) selected among metastatic breast cancer (MBC) patients included in a retrospective study from the Epidemiological Strategy and Medical Economics (ESME) MBC cohort.

Keywords: Neurological progression-free survival; Brain metastases; Metastatic breast cancer

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Cancer

David Pasquier, Amélie Darlix, Guillaume Louvel, Julien Fraisse, William Jacot, et al.. Treatment and outcomes in patients with central nervous system metastases from breast cancer in the real-life ESME MBC cohort. European Journal of Cancer, 2020, 125, pp.22-30. ⟨10.1016/j.ejca.2019.11.001⟩. ⟨hal-02887998⟩